A demonstration that embryonic mouse liver heterogenous nuclear ribonucleic acid contains globin messenger ribonucleic acid sequences
نویسندگان
چکیده
منابع مشابه
Studies on Liver Messenger Ribonucleic Acid.
Strong evidence has accumulated in recent years in favor of the following scheme of protein biosynthesis. DNA directs the formation of complementary strands of messenger RNA which possess the necessary genetic information to determine the sequential arrangement of amino acids in polypeptide chains (1, 2). The messenger RNA attaches itself to ribosomes to form a multiple ribosomal structure, the...
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Polyadenylate sequences are found covalently linked to yeast mRNA molecules. The poly(A) sequences are relatively homogeneous in size and have an average chain length of about 50 residues. They are located at the 3’ end of the mRNA molecule. Our data suggest that some mRNA molecules may not contain poly(A) sequences and that no poly(A) sequences are present in rRNA. The occurrence of poly(A) se...
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The synthesis of DNA complementary to rabbit globin mRNA by the enzyme RNA-directed DNA polymerase (from avian myeloblastosis virus) has been studied. The reaction is dependent on mRNA as template, oligo(dT) as primer, and the four deoxynucleoside triphosphates as substrates. The 28 S, 18 S, and 4 S RNA are not effective templates; oligo(dG), oligo(dC), and oligo(dA) are not effective primers. ...
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Poly(A) sequences are covalently bound to the 3’ termini of mRNA and many heterogeneous nuclear RNA molecules of HeLa cells. Localization of the poly(A) sequences has been established in these experiments by the observation that a large fraction of the label introduced in the oxidized 2’,3’cis-glycol groups of these RNAs by sodium borohydride reduction, is recovered in the poly(A) sequences rel...
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1. Steady-state poly(A)-containing nuclear RNA was isolated from the lactating guinea-pig mammary gland and analysed by sucrose-gradient centrifugation under denaturing conditions. 2. Nucleic acid-hybridization studies demonstrated the presence of small amounts of high-molecular-weight RNA species containing milk-protein mRNA sequences sedimenting at 25S. These were not found in the post-nuclea...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1972
ISSN: 0306-3283
DOI: 10.1042/bj1280092p